Psychosis associated to Parkinson's disease in the early stages: relevance of cognitive decline and depression
Identifieur interne : 000072 ( Main/Exploration ); précédent : 000071; suivant : 000073Psychosis associated to Parkinson's disease in the early stages: relevance of cognitive decline and depression
Auteurs : Letterio Morgante [Italie] ; Carlo Colosimo [Italie] ; Angelo Antonini [Italie] ; Roberto Marconi [Italie] ; Giuseppe Meco [Italie] ; Massimo Pederzoli [Italie] ; Francesco E. Pontieri [Italie] ; Giulio Cicarelli [Italie] ; Giovanni Abbruzzese [Italie] ; Salvatore Zappulla [Italie] ; Silvia Ramat [Italie] ; Michela Manfredi [Italie] ; Edo Bottacchi [Italie] ; Michele Abrignani [Italie] ; Alfredo Berardelli [Italie] ; Autilia Cozzolino [Italie] ; Claudio Paradiso [Italie] ; Danilo De Gaspari [Italie] ; Francesca Morgante [Italie] ; Paolo Barone [Italie]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2012-01.
Abstract
Objective To evaluate the prevalence of psychosis associated with Parkinson's disease (PSY-PD) in its early stages, its incidence over a 24 month follow-up period and the association with motor and non-motor clinical features. Methods PRIAMO is a 2 year longitudinal observational study that has enrolled patients with parkinsonism in 55 Italian centres. A cohort of 495 patients with early disease stage PD (baseline Hoehn and Yahr score ≤2, disease's duration (median) 3.4 years) were followed for 2 years. PSY-PD was evaluated by means of a clinician rated questionnaire and defined as the presence of at least one of the following symptoms occurring for at least 1 month: illusions, hallucinations, jealousy ideas and persecutory ideas. Patients with and without PSY-PD were compared on several clinical variables, encompassing motor and non-motor features. Results The prevalence of PSY-PD at baseline was 3%; the incidences at 12 and 24 months were 5.2% and 7.7%, respectively. Longer disease duration and prescription of dopamine agonists at baseline were associated with the development of PSY-PD over the 24 month period. At this follow-up time, worse disease severity, decline in cognitive performances, presence of depressive symptoms and anxiety were more frequently observed in PSY-PD. Conclusions Psychotic type symptoms may occur in the early stages of PD although less frequently than in later stages. Beyond dopaminergic treatment, there are disease related factors, such as disease severity and the occurrence of cognitive and depressive symptoms, which may underlie the onset of psychotic type symptoms from the earliest stages.
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DOI: 10.1136/jnnp-2011-300043
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Pontieri</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Sant'Andrea, II facoltà di Medicina e Chirurgia, Sapienza Università di Roma, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Cicarelli, Giulio" sort="Cicarelli, Giulio" uniqKey="Cicarelli G" first="Giulio" last="Cicarelli">Giulio Cicarelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia e Stroke, AORN San Giuseppe Moscati, Avellino</wicri:regionArea><wicri:noRegion>Avellino</wicri:noRegion></affiliation></author><author><name sortKey="Abbruzzese, Giovanni" sort="Abbruzzese, Giovanni" uniqKey="Abbruzzese G" first="Giovanni" last="Abbruzzese">Giovanni Abbruzzese</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Centro Parkinson-Dipartimento di Neuroscienze, Oftalmologia e Genetica, Università degli Studi di Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Zappulla, Salvatore" sort="Zappulla, Salvatore" uniqKey="Zappulla S" first="Salvatore" last="Zappulla">Salvatore Zappulla</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia, Ospedale Umberto I, Enna</wicri:regionArea><wicri:noRegion>Enna</wicri:noRegion></affiliation></author><author><name sortKey="Ramat, Silvia" sort="Ramat, Silvia" uniqKey="Ramat S" first="Silvia" last="Ramat">Silvia Ramat</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica, Azienda Ospedaliera Universitaria, Firenze</wicri:regionArea><wicri:noRegion>Firenze</wicri:noRegion></affiliation></author><author><name sortKey="Manfredi, Michela" sort="Manfredi, Michela" uniqKey="Manfredi M" first="Michela" last="Manfredi">Michela Manfredi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Fondazione Salvatore Maugeri IRCCS, Castel Goffredo, Mantova</wicri:regionArea><wicri:noRegion>Mantova</wicri:noRegion></affiliation></author><author><name sortKey="Bottacchi, Edo" sort="Bottacchi, Edo" uniqKey="Bottacchi E" first="Edo" last="Bottacchi">Edo Bottacchi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>UO di Neurologia, Ospedale Regionale, Aosta</wicri:regionArea><wicri:noRegion>Aosta</wicri:noRegion></affiliation></author><author><name sortKey="Abrignani, Michele" sort="Abrignani, Michele" uniqKey="Abrignani M" first="Michele" last="Abrignani">Michele Abrignani</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>UO Neurologia, Ospedale San Biagio di Marsala, Marsala, Trapani</wicri:regionArea><wicri:noRegion>Trapani</wicri:noRegion></affiliation></author><author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Neurologiche and Neuromed Institute, Sapienza Università di Roma, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Università Federico II and IDC-Hermitage-Capodimonte, Napoli</wicri:regionArea><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Paradiso, Claudio" sort="Paradiso, Claudio" uniqKey="Paradiso C" first="Claudio" last="Paradiso">Claudio Paradiso</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Istituti Clinici di Perfezionamento, Parkinson Institute, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="De Gaspari, Danilo" sort="De Gaspari, Danilo" uniqKey="De Gaspari D" first="Danilo" last="De Gaspari">Danilo De Gaspari</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Istituti Clinici di Perfezionamento, Parkinson Institute, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche Università di Messina, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Università Federico II and IDC-Hermitage-Capodimonte, Napoli</wicri:regionArea><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2012-01">2012-01</date><biblScope unit="volume">83</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="76">76</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">2C91C9CEDEB7A5926BCC791D7875A0BDB9CF2502</idno><idno type="DOI">10.1136/jnnp-2011-300043</idno><idno type="href">jnnp-83-76.pdf</idno><idno type="ArticleID">jnnp-2011-300043</idno><idno type="PMID">21836035</idno><idno type="local">jnnp;83/1/76</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective To evaluate the prevalence of psychosis associated with Parkinson's disease (PSY-PD) in its early stages, its incidence over a 24 month follow-up period and the association with motor and non-motor clinical features. Methods PRIAMO is a 2 year longitudinal observational study that has enrolled patients with parkinsonism in 55 Italian centres. A cohort of 495 patients with early disease stage PD (baseline Hoehn and Yahr score ≤2, disease's duration (median) 3.4 years) were followed for 2 years. PSY-PD was evaluated by means of a clinician rated questionnaire and defined as the presence of at least one of the following symptoms occurring for at least 1 month: illusions, hallucinations, jealousy ideas and persecutory ideas. Patients with and without PSY-PD were compared on several clinical variables, encompassing motor and non-motor features. Results The prevalence of PSY-PD at baseline was 3%; the incidences at 12 and 24 months were 5.2% and 7.7%, respectively. Longer disease duration and prescription of dopamine agonists at baseline were associated with the development of PSY-PD over the 24 month period. At this follow-up time, worse disease severity, decline in cognitive performances, presence of depressive symptoms and anxiety were more frequently observed in PSY-PD. Conclusions Psychotic type symptoms may occur in the early stages of PD although less frequently than in later stages. Beyond dopaminergic treatment, there are disease related factors, such as disease severity and the occurrence of cognitive and depressive symptoms, which may underlie the onset of psychotic type symptoms from the earliest stages.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name></noRegion><name sortKey="Abbruzzese, Giovanni" sort="Abbruzzese, Giovanni" uniqKey="Abbruzzese G" first="Giovanni" last="Abbruzzese">Giovanni Abbruzzese</name><name sortKey="Abrignani, Michele" sort="Abrignani, Michele" uniqKey="Abrignani M" first="Michele" last="Abrignani">Michele Abrignani</name><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><name sortKey="Bottacchi, Edo" sort="Bottacchi, Edo" uniqKey="Bottacchi E" first="Edo" last="Bottacchi">Edo Bottacchi</name><name sortKey="Cicarelli, Giulio" sort="Cicarelli, Giulio" uniqKey="Cicarelli G" first="Giulio" last="Cicarelli">Giulio Cicarelli</name><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name><name sortKey="De Gaspari, Danilo" sort="De Gaspari, Danilo" uniqKey="De Gaspari D" first="Danilo" last="De Gaspari">Danilo De Gaspari</name><name sortKey="Manfredi, Michela" sort="Manfredi, Michela" uniqKey="Manfredi M" first="Michela" last="Manfredi">Michela Manfredi</name><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name><name sortKey="Paradiso, Claudio" sort="Paradiso, Claudio" uniqKey="Paradiso C" first="Claudio" last="Paradiso">Claudio Paradiso</name><name sortKey="Pederzoli, Massimo" sort="Pederzoli, Massimo" uniqKey="Pederzoli M" first="Massimo" last="Pederzoli">Massimo Pederzoli</name><name sortKey="Pontieri, Francesco E" sort="Pontieri, Francesco E" uniqKey="Pontieri F" first="Francesco E" last="Pontieri">Francesco E. Pontieri</name><name sortKey="Ramat, Silvia" sort="Ramat, Silvia" uniqKey="Ramat S" first="Silvia" last="Ramat">Silvia Ramat</name><name sortKey="Zappulla, Salvatore" sort="Zappulla, Salvatore" uniqKey="Zappulla S" first="Salvatore" last="Zappulla">Salvatore Zappulla</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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